As reported by David McDonnell of the Daily Mirror, the Argentina international appeared to roll his ankle in the second half of City's clash with Southampton, and he left the pitch visibly limping, to be replaced by Wilfried Bony.
The 27-year-old has been the Citizens' top attacking option when healthy, but he has already missed a significant part of the season with a hamstring injury he suffered while away on international duty with Argentina.
As reported by sport, it is but the latest in a long line of knocks and injuries that have slowed down the former ace.
Kevin De Bruyne and Raheem Sterling did a fine job carrying the scoring load in October, when Aguero was sidelined, and in Bony, City have a capable backup adept at holding onto the ball and presenting a target inside the box.
Aguero's surging runs and killer instinct were missed back then, however, and things won't be different this time around. The pocket-sized striker is one of the most uniquely gifted players in the world and belongs to a small, elite group of players who simply can't be replaced.
His absence may open the door for young starlet Kelechi Iheanacho to get some more minutes after his promising debut earlier this year, where he impressed by scoring the winning goal against Crystal Palace in his second-ever Premier League contest.
Fabian Johnson just can¡¯t stop won¡¯t stop scoring. The American winger opened the scoring for Borussia Monchengladbach inside of five minutes against Hoffenheim but TSG were able to shake it off and build a 3-1 lead.
Johnson though wasn¡¯t done. After Josep Drmic pulled one back for ¡®Gladbach in the 56th minute, Johnson came flying down the right wing late in the match. Upon getting into the box, Fabian pulled it back onto his left foot, before finishing off a tremendous equalizer for his second of the match.
The Dynamos thus became the second team after defending champions Atletico de Kolkata to qualify for the last four stage with 21 points from 12 games. They still have two league matches left after this. North East are virtually out of contention with 17 points from 13 games.
While India international Robin Singh's opportunistic strike in the 20th minute provided lead to the Delhi franchise, his national team colleague Seityasen Singh equalised within seven minutes.
It was Dos Santos' angular left-footer in the 88th minute that sealed the deal for Delhi.
The winners were today wearing an away jersey that resembled Catalan giants Barcelona's home jersey.
Delhi got the lead at the stroke of half an hour when North East goalkeeper TP Rehneesh's feeble punch fell infront as Robin showed good poaching ability with a crisp right footer much to the delight of his mother Caroline Singh, sitting in the stands.
However the joy was short-lived as Seityasen latched onto a miss pass from Ralte Adinga to enter the box and beat the Delhi goalie Antonio Doblas with immaculate placement that also had power.
After being locked 1-1 at half time, the teams traded moves in the second half without making any decisive inroads into the opposition citadel.
In the end it was 'Super Sub' Dos Santos, whose brilliant left-foot which has delighted the Delhi fans since last season got into act. Getting a ball at the top of the box, he first did the spadework to beat an opposition defender and then unleashed a left-footer with the outstep that went past the roght of goalkeeper Rahneesh as the partisan crowd were stunned into silence.More about news: